Drug interactions
Aspirin + Fosinopril-hydrochlorothiazide
Severity: Moderate
Aspirin and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At anti-inflammatory or analgesic doses, aspirin may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide and impair renal function, especially in dehydrated or older patients. Low-dose cardioprotective aspirin has much less effect.
What this interaction means in plain words
Aspirin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal blood flow and sodium excretion, opposing ACE inhibitor and diuretic effects.
What to do
Low-dose aspirin can generally continue with routine blood pressure monitoring; with higher doses monitor creatinine, potassium and blood pressure and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At anti-inflammatory or analgesic doses, aspirin may reduce the antihypertensive effect of fosinopril and hydrochlorothiazide and impair renal function, especially in dehydrated or older patients. Low-dose cardioprotective aspirin has much less effect.
How serious is the interaction between Aspirin and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Low-dose aspirin can generally continue with routine blood pressure monitoring; with higher doses monitor creatinine, potassium and blood pressure and maintain hydration.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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