Drug interactions
Aspirin + Hydrochlorothiazide-losartan
Severity: Moderate
Aspirin and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic or anti-inflammatory doses of aspirin can reduce the blood pressure effect of losartan and hydrochlorothiazide and can worsen renal function, especially in elderly or volume-depleted patients. Low-dose aspirin for cardioprotection has little effect.
What this interaction means in plain words
Aspirin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces renal blood flow and sodium excretion, opposing antihypertensive and diuretic effects.
What to do
Prefer low-dose aspirin where antiplatelet therapy is needed and monitor blood pressure, creatinine and potassium with higher doses. Maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Aspirin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Aspirin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic or anti-inflammatory doses of aspirin can reduce the blood pressure effect of losartan and hydrochlorothiazide and can worsen renal function, especially in elderly or volume-depleted patients. Low-dose aspirin for cardioprotection has little effect.
How serious is the interaction between Aspirin and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin where antiplatelet therapy is needed and monitor blood pressure, creatinine and potassium with higher doses. Maintain hydration.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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