Drug interactions
Dofetilide + Hydrochlorothiazide-losartan
Severity: Contraindicated
Dofetilide and Hydrochlorothiazide-losartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Dofetilide and Hydrochlorothiazide-losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Reduced renal tubular secretion of dofetilide plus thiazide-induced electrolyte depletion promotes QT prolongation.
What to do
Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dofetilide and Hydrochlorothiazide-losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
- Amiloride + Hydrochlorothiazide-losartan Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as contraindicated. Dofetilide and Hydrochlorothiazide-losartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels and also causes hypokalemia and hypomagnesemia. Higher exposure and electrolyte disturbance increase the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dofetilide and Hydrochlorothiazide-losartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as it is contraindicated in dofetilide labeling; choose a non-thiazide antihypertensive. Correct electrolytes and monitor ECG if dofetilide is used.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Hydrochlorothiazide-losartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
