Drug interactions
Acetylsalicylic acid + Labetalol
Severity: Minor
Acetylsalicylic acid and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular use of higher-dose aspirin may weaken the antihypertensive effect of labetalol. The effect is mainly relevant with sustained anti-inflammatory dosing rather than low-dose aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
Inhibition of vasodilatory prostaglandin synthesis causes sodium and water retention and raises vascular resistance, opposing beta-blocker effect.
What to do
Monitor blood pressure if aspirin is used regularly at analgesic or anti-inflammatory doses. Low-dose aspirin generally needs no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Labetalol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Acetylsalicylic acid with Labetalol?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Regular use of higher-dose aspirin may weaken the antihypertensive effect of labetalol. The effect is mainly relevant with sustained anti-inflammatory dosing rather than low-dose aspirin.
How serious is the interaction between Acetylsalicylic acid and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if aspirin is used regularly at analgesic or anti-inflammatory doses. Low-dose aspirin generally needs no change.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
