Drug interactions
Bisoprolol + Labetalol
Severity: Major
Bisoprolol and Labetalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents block beta receptors, and labetalol also blocks alpha-1 receptors, so the combination duplicates therapy. It can cause bradycardia, marked hypotension and AV block.
What this interaction means in plain words
Bisoprolol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bisoprolol belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade plus alpha-1 blockade from labetalol.
What to do
Avoid combining; use one beta-blocker only. If overlap occurs, stop one and monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bisoprolol
Other interactions of Labetalol
Frequently asked questions
Can I take Bisoprolol with Labetalol?
MediHelp rates the interaction as major. Bisoprolol and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents block beta receptors, and labetalol also blocks alpha-1 receptors, so the combination duplicates therapy. It can cause bradycardia, marked hypotension and AV block.
How serious is the interaction between Bisoprolol and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use one beta-blocker only. If overlap occurs, stop one and monitor heart rate and blood pressure.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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