Drug interactions
Atenolol-chlorthalidone + Labetalol
Severity: Major
Atenolol-chlorthalidone and Labetalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol combines alpha- and beta-blockade, and adding atenolol duplicates beta-blockade. This raises the risk of bradycardia, hypotension and heart block.
What this interaction means in plain words
Atenolol-chlorthalidone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade (therapeutic duplication), with added alpha-1 blockade from labetalol.
What to do
Avoid combining two beta-blockers; select one agent. If overlap is unavoidable, monitor heart rate and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Atenolol-chlorthalidone
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
- Budesonide-formoterol + Labetalol Major
Frequently asked questions
Can I take Atenolol-chlorthalidone with Labetalol?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Labetalol combines alpha- and beta-blockade, and adding atenolol duplicates beta-blockade. This raises the risk of bradycardia, hypotension and heart block.
How serious is the interaction between Atenolol-chlorthalidone and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two beta-blockers; select one agent. If overlap is unavoidable, monitor heart rate and blood pressure.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
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