Drug interactions
Amiodarone + Labetalol
Severity: Major
Amiodarone and Labetalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow heart rate and AV conduction, so combined use may cause marked bradycardia, AV block or sinus arrest. Hypotension can also occur, and the risk is highest in patients with conduction disease or left ventricular dysfunction.
What this interaction means in plain words
Amiodarone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects from beta-blockade and amiodarone's sodium, potassium, calcium channel and beta-blocking actions.
What to do
Monitor heart rate, ECG and blood pressure, particularly when starting amiodarone or adjusting doses. Reduce the labetalol dose or stop if symptomatic bradycardia or conduction block develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Labetalol
Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Frequently asked questions
Can I take Amiodarone with Labetalol?
MediHelp rates the interaction as major. Amiodarone and Labetalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow heart rate and AV conduction, so combined use may cause marked bradycardia, AV block or sinus arrest. Hypotension can also occur, and the risk is highest in patients with conduction disease or left ventricular dysfunction.
How serious is the interaction between Amiodarone and Labetalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure, particularly when starting amiodarone or adjusting doses. Reduce the labetalol dose or stop if symptomatic bradycardia or conduction block develops.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Atenolol-chlorthalidone, Atenolol. The full list is on the Labetalol page.
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