Drug interactions
Acetylsalicylic acid + Losartan
Severity: Moderate
Acetylsalicylic acid and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-inflammatory doses of aspirin can reduce the antihypertensive effect of losartan and increase the risk of renal function decline, especially in elderly or volume-depleted patients. Low-dose aspirin carries much less risk.
What this interaction means in plain words
Acetylsalicylic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
Aspirin inhibits renal vasodilatory prostaglandins, reducing renal perfusion and opposing ARB-mediated blood pressure reduction, while ARB lowers glomerular filtration pressure.
What to do
Monitor blood pressure, creatinine and potassium when aspirin is used at higher doses; maintain hydration and prefer low-dose aspirin or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Acetylsalicylic acid with Losartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-inflammatory doses of aspirin can reduce the antihypertensive effect of losartan and increase the risk of renal function decline, especially in elderly or volume-depleted patients. Low-dose aspirin carries much less risk.
How serious is the interaction between Acetylsalicylic acid and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium when aspirin is used at higher doses; maintain hydration and prefer low-dose aspirin or an alternative analgesic.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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