Drug interactions
Losartan + Sparsentan
Severity: Contraindicated
Losartan and Sparsentan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and renal function decline.
What this interaction means in plain words
Losartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Losartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
Why it happens
Duplicate angiotensin II type 1 receptor blockade producing additive pharmacodynamic effects.
What to do
Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function after initiation.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Losartan
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Losartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Losartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan is a dual endothelin and angiotensin II receptor antagonist, so adding an ARB duplicates angiotensin receptor blockade. This increases the risk of hypotension, syncope, hyperkalemia and renal function decline.
How serious is the interaction between Losartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop the ARB before starting sparsentan. Monitor blood pressure, potassium and renal function after initiation.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Amifostine, Amiloride. The full list is on the Losartan page.
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