Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Losartan
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two angiotensin receptor blockers (valsartan plus losartan) gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Duplicate angiotensin II type 1 receptor blockade produces additive hypotension, reduced aldosterone effect, and reduced glomerular filtration.
What to do
Avoid using two ARBs together; keep a single agent. If both were taken, stop one and check serum potassium and creatinine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-olmesartan-hydrochlorothiazide + Losartan Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Losartan?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two angiotensin receptor blockers (valsartan plus losartan) gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two ARBs together; keep a single agent. If both were taken, stop one and check serum potassium and creatinine.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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