Drug interactions
Acetylsalicylic acid + Nabumetone
Severity: Major
Acetylsalicylic acid and Nabumetone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining aspirin with nabumetone increases the risk of gastrointestinal ulceration and bleeding. The NSAID may also weaken the antiplatelet effect of low-dose aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive COX inhibition lowers mucosal prostaglandins and platelet function, with potential competition at platelet COX-1.
What to do
Avoid combination where possible; if needed, add a proton pump inhibitor and monitor for GI bleeding. Take aspirin before the NSAID when both are needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Alteplase + Nabumetone Major
- Amiloride + Nabumetone Major
Frequently asked questions
Can I take Acetylsalicylic acid with Nabumetone?
MediHelp rates the interaction as major. Acetylsalicylic acid and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with nabumetone increases the risk of gastrointestinal ulceration and bleeding. The NSAID may also weaken the antiplatelet effect of low-dose aspirin.
How serious is the interaction between Acetylsalicylic acid and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if needed, add a proton pump inhibitor and monitor for GI bleeding. Take aspirin before the NSAID when both are needed.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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