Drug reference
nabumetone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity
Common side effects
- Flatulence
- Dyspepsia
- Constipation
- Dizziness
- Edema
- Abdominal pain
- Diarrhea
Contraindications
- Absolute: Aspirin allergy, severe renal impairment; perioperative pain in setting of coronary artery bypass graft (CABG) surgery Relative: Duodenal/gastric/peptic ulcer, stomatitis, systemic lupus erythematosus, ulcerative colitis, late pregnancy (may cause premature closure of ductus arteriosus)
Related conditions
Frequently asked questions
What drug class is nabumetone?
nabumetone belongs to: Musculoskeletal.
How does nabumetone work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity
What are the common side effects of nabumetone?
Flatulence, Dyspepsia, Constipation, Dizziness, Edema, Abdominal pain, Diarrhea
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