Drug interactions
Ketorolac intranasal + Nabumetone
Severity: Contraindicated
Ketorolac intranasal and Nabumetone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking nabumetone with intranasal ketorolac duplicates NSAID therapy and increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. Ketorolac labeling prohibits concurrent NSAID use.
What this interaction means in plain words
Ketorolac intranasal and Nabumetone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Do not co-administer; select one NSAID only. Consider non-NSAID analgesics for additional relief.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketorolac intranasal and Nabumetone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nabumetone
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
- Amiloride + Nabumetone Major
Frequently asked questions
Can I take Ketorolac intranasal with Nabumetone?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Nabumetone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Taking nabumetone with intranasal ketorolac duplicates NSAID therapy and increases the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. Ketorolac labeling prohibits concurrent NSAID use.
How serious is the interaction between Ketorolac intranasal and Nabumetone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select one NSAID only. Consider non-NSAID analgesics for additional relief.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Nabumetone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
