Drug interactions
Ketorolac + Nabumetone
Severity: Contraindicated
Ketorolac and Nabumetone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining nabumetone with ketorolac increases gastrointestinal, renal and bleeding risks without added analgesia. Ketorolac is contraindicated with other NSAIDs.
What this interaction means in plain words
Ketorolac and Nabumetone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketorolac belongs to Musculoskeletal; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Do not combine; use a single NSAID at the lowest effective dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
- Amiloride + Nabumetone Major
Frequently asked questions
Can I take Ketorolac with Nabumetone?
MediHelp rates the interaction as contraindicated. Ketorolac and Nabumetone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining nabumetone with ketorolac increases gastrointestinal, renal and bleeding risks without added analgesia. Ketorolac is contraindicated with other NSAIDs.
How serious is the interaction between Ketorolac and Nabumetone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single NSAID at the lowest effective dose.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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