Drug interactions
Acetylsalicylic acid + Oxaprozin
Severity: Major
Acetylsalicylic acid and Oxaprozin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking aspirin with oxaprozin increases the risk of gastrointestinal ulceration and bleeding. The NSAID may also reduce the antiplatelet benefit of low-dose aspirin.
What this interaction means in plain words
Acetylsalicylic acid and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Oxaprozin belongs to Musculoskeletal.
Why it happens
Additive COX inhibition impairs gastric mucosal protection and platelet aggregation, with possible competition at platelet COX-1.
What to do
Avoid the combination if possible; if needed, add a proton pump inhibitor and monitor for GI bleeding. Take aspirin before the NSAID.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Alteplase + Oxaprozin Major
- Amiloride + Oxaprozin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Oxaprozin?
MediHelp rates the interaction as major. Acetylsalicylic acid and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking aspirin with oxaprozin increases the risk of gastrointestinal ulceration and bleeding. The NSAID may also reduce the antiplatelet benefit of low-dose aspirin.
How serious is the interaction between Acetylsalicylic acid and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, add a proton pump inhibitor and monitor for GI bleeding. Take aspirin before the NSAID.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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