Drug interactions
Acetylsalicylic acid + Piroxicam
Severity: Major
Acetylsalicylic acid and Piroxicam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining aspirin with piroxicam increases the risk of gastrointestinal ulceration and bleeding. Piroxicam may also interfere with the antiplatelet cardioprotective effect of low-dose aspirin, and the combination adds renal risk.
What this interaction means in plain words
Acetylsalicylic acid and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Piroxicam belongs to Musculoskeletal.
Why it happens
Both inhibit COX-mediated gastroprotective prostaglandins and platelet function, and piroxicam may compete with aspirin at the COX-1 binding site.
What to do
Avoid routine combination; if aspirin is taken for cardioprotection, choose an alternative analgesic or add gastroprotection with a PPI. Monitor for GI bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Alteplase + Piroxicam Major
- Amiloride + Piroxicam Major
Frequently asked questions
Can I take Acetylsalicylic acid with Piroxicam?
MediHelp rates the interaction as major. Acetylsalicylic acid and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with piroxicam increases the risk of gastrointestinal ulceration and bleeding. Piroxicam may also interfere with the antiplatelet cardioprotective effect of low-dose aspirin, and the combination adds renal risk.
How serious is the interaction between Acetylsalicylic acid and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if aspirin is taken for cardioprotection, choose an alternative analgesic or add gastroprotection with a PPI. Monitor for GI bleeding and renal function.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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