Drug reference
piroxicam
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase; at least 2 isoenzymes, cyclooxygenase-1 (COX-1) & -2 (COX-2)
Common side effects
- Constipation
- Anorexia
- Fatigue
- Nausea
- Abdominal pain
- Diarrhea
Contraindications
- Absolute: ASA allergy Relative: bleeding disorders, duodenal/gastric/peptic ulcer, stomatitis, SLE, ulcerative colitis, upper GI disease, late pregnancy (may cause premature closure of the ductus arteriosus)
Known interactions (3)
- Diclofenac + piroxicam Major
- Isotretinoin + piroxicam Moderate
- piroxicam + Tizanidine Moderate
Related conditions
Frequently asked questions
What drug class is piroxicam?
piroxicam belongs to: Musculoskeletal.
How does piroxicam work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase; at least 2 isoenzymes, cyclooxygenase-1 (COX-1) & -2 (COX-2)
What are the common side effects of piroxicam?
Constipation, Anorexia, Fatigue, Nausea, Abdominal pain, Diarrhea
Which drugs interact with piroxicam?
Diclofenac, Isotretinoin, Tizanidine
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