Drug interactions
Ketorolac intranasal + Piroxicam
Severity: Contraindicated
Ketorolac intranasal and Piroxicam: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam with intranasal ketorolac duplicates NSAID therapy and raises the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Piroxicam has a long half-life, so overlap persists after it is stopped.
What this interaction means in plain words
Ketorolac intranasal and Piroxicam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Avoid the combination; allow for piroxicam's long half-life before starting ketorolac, or use a non-NSAID analgesic instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Piroxicam
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
- Amiloride + Piroxicam Major
Frequently asked questions
Can I take Ketorolac intranasal with Piroxicam?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Piroxicam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Piroxicam with intranasal ketorolac duplicates NSAID therapy and raises the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Piroxicam has a long half-life, so overlap persists after it is stopped.
How serious is the interaction between Ketorolac intranasal and Piroxicam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; allow for piroxicam's long half-life before starting ketorolac, or use a non-NSAID analgesic instead.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Piroxicam page.
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