Drug interactions
Aspirin / citric acid / sodium bicarbonate + Azilsartan-chlorthalidone
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Azilsartan-chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is given at analgesic doses and can reduce the antihypertensive effect of azilsartan and chlorthalidone while impairing renal function, especially in elderly or volume-depleted patients. The product also carries a notable sodium load that may further affect blood pressure and fluid balance.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and promotes sodium retention, with added sodium from bicarbonate.
What to do
Monitor blood pressure and renal function with regular use, avoid prolonged use, and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Azilsartan-chlorthalidone?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Azilsartan-chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is given at analgesic doses and can reduce the antihypertensive effect of azilsartan and chlorthalidone while impairing renal function, especially in elderly or volume-depleted patients. The product also carries a notable sodium load that may further affect blood pressure and fluid balance.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Azilsartan-chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function with regular use, avoid prolonged use, and maintain hydration.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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