Drug interactions
Aspirin / citric acid / sodium bicarbonate + Azilsartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Azilsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The analgesic-dose aspirin in this effervescent product can blunt azilsartan's blood pressure effect and worsen renal function in volume-depleted or older patients. The sodium load may also contribute to reduced antihypertensive effect.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibition of renal prostaglandins reduces renal perfusion and opposes ARB effect, with added sodium load from the formulation.
What to do
Monitor blood pressure and renal function with regular use, and prefer a non-NSAID analgesic like paracetamol where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Azilsartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The analgesic-dose aspirin in this effervescent product can blunt azilsartan's blood pressure effect and worsen renal function in volume-depleted or older patients. The sodium load may also contribute to reduced antihypertensive effect.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Azilsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function with regular use, and prefer a non-NSAID analgesic like paracetamol where appropriate.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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