Drug interactions
Aspirin / citric acid / sodium bicarbonate + Candesartan-hydrochlorothiazide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is given at analgesic doses and may weaken the antihypertensive action of candesartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of renal impairment in elderly or dehydrated patients. The sodium load may also oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, reducing renal blood flow and natriuresis, while the sodium content adds to fluid retention.
What to do
Limit use to short courses and keep the patient hydrated. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is given at analgesic doses and may weaken the antihypertensive action of candesartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of renal impairment in elderly or dehydrated patients. The sodium load may also oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses and keep the patient hydrated. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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