Drug interactions
Aspirin / citric acid / sodium bicarbonate + Captopril-hydrochlorothiazide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can reduce the blood pressure and diuretic response to captopril and hydrochlorothiazide and may impair renal function in volume-depleted or older patients. The sodium bicarbonate content adds a sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion, opposing ACE inhibitor and diuretic effects.
What to do
Monitor blood pressure and renal function if regular use is needed, and ensure adequate hydration. Prefer an alternative analgesic without sodium load for repeated dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can reduce the blood pressure and diuretic response to captopril and hydrochlorothiazide and may impair renal function in volume-depleted or older patients. The sodium bicarbonate content adds a sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function if regular use is needed, and ensure adequate hydration. Prefer an alternative analgesic without sodium load for repeated dosing.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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