Drug interactions
Aspirin / citric acid / sodium bicarbonate + Cefixime
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Cefixime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin component is a salicylate cleared in part by renal tubular secretion, which cefixime may compete for. The effect is likely small, and bicarbonate alkalinizes urine, which increases salicylate excretion.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport between cefixime and salicylate.
What to do
No routine action is needed; monitor for salicylate toxicity signs (tinnitus) in renal impairment or with frequent dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Cefixime?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The aspirin component is a salicylate cleared in part by renal tubular secretion, which cefixime may compete for. The effect is likely small, and bicarbonate alkalinizes urine, which increases salicylate excretion.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Cefixime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for salicylate toxicity signs (tinnitus) in renal impairment or with frequent dosing.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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