Drug interactions
Aspirin / citric acid / sodium bicarbonate + Celecoxib
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product adds antiplatelet activity and gastric irritation to celecoxib, increasing the risk of gastrointestinal bleeding. The buffering does not remove the systemic effect of aspirin.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive mucosal injury and aspirin-induced irreversible platelet inhibition on top of NSAID effects.
What to do
Avoid routine concurrent use for pain relief and use gastroprotection if both are needed. Monitor for GI bleeding signs and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Celecoxib?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product adds antiplatelet activity and gastric irritation to celecoxib, increasing the risk of gastrointestinal bleeding. The buffering does not remove the systemic effect of aspirin.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use for pain relief and use gastroprotection if both are needed. Monitor for GI bleeding signs and anemia.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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