Drug interactions
Aspirin / citric acid / sodium bicarbonate + Cilostazol
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent preparation adds antiplatelet activity to cilostazol, which can increase the risk of bruising and bleeding. Analgesic-dose aspirin raises gastrointestinal bleeding risk further. The sodium bicarbonate component does not alter this.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects through PDE3 inhibition and COX-1 inhibition.
What to do
Monitor for bleeding and anemia, and limit the aspirin to the lowest needed dose and shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Cilostazol?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent preparation adds antiplatelet activity to cilostazol, which can increase the risk of bruising and bleeding. Analgesic-dose aspirin raises gastrointestinal bleeding risk further. The sodium bicarbonate component does not alter this.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and anemia, and limit the aspirin to the lowest needed dose and shortest duration.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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