Drug interactions
Aspirin / citric acid / sodium bicarbonate + Eltrombopag
Severity: Minor
Aspirin / citric acid / sodium bicarbonate and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate is partly cleared by glucuronidation, and eltrombopag inhibits UGT enzymes in vitro. The clinical importance is unclear. Aspirin's antiplatelet effect adds bleeding concern in thrombocytopenic patients.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of UGT-mediated salicylate glucuronidation by eltrombopag, shown in vitro only.
What to do
No kinetic dose adjustment is needed. Limit use in patients with low platelet counts and monitor for bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Eltrombopag?
MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylate is partly cleared by glucuronidation, and eltrombopag inhibits UGT enzymes in vitro. The clinical importance is unclear. Aspirin's antiplatelet effect adds bleeding concern in thrombocytopenic patients.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No kinetic dose adjustment is needed. Limit use in patients with low platelet counts and monitor for bleeding.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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