Drug interactions
Aspirin / citric acid / sodium bicarbonate + Enalapril-hydrochlorothiazide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can reduce the antihypertensive effect of ACE inhibitors and diuretics and may impair renal function in volume-depleted patients. The sodium bicarbonate content adds a sodium load that may also oppose blood-pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits prostaglandin synthesis, reducing renal blood flow and sodium excretion, while bicarbonate adds sodium.
What to do
Limit use to short courses, maintain hydration, and monitor blood pressure and renal function; avoid in heart failure or kidney disease where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can reduce the antihypertensive effect of ACE inhibitors and diuretics and may impair renal function in volume-depleted patients. The sodium bicarbonate content adds a sodium load that may also oppose blood-pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses, maintain hydration, and monitor blood pressure and renal function; avoid in heart failure or kidney disease where possible.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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