Drug interactions
Aspirin / citric acid / sodium bicarbonate + Fosinopril-hydrochlorothiazide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic-dose aspirin can blunt the antihypertensive effect of ACE inhibitors and thiazides by reducing vasodilatory prostaglandins and promoting sodium retention. Together with a diuretic and ACE inhibitor it may also impair renal function, especially in elderly or volume-depleted patients. The sodium bicarbonate content adds a sodium load.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibition of prostaglandin synthesis reduces renal blood flow and sodium excretion, antagonizing ACE inhibitor and diuretic effects.
What to do
Avoid regular use of effervescent analgesic-dose aspirin; use occasional doses only and ensure hydration. Monitor blood pressure and serum creatinine and potassium if use is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic-dose aspirin can blunt the antihypertensive effect of ACE inhibitors and thiazides by reducing vasodilatory prostaglandins and promoting sodium retention. Together with a diuretic and ACE inhibitor it may also impair renal function, especially in elderly or volume-depleted patients. The sodium bicarbonate content adds a sodium load.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of effervescent analgesic-dose aspirin; use occasional doses only and ensure hydration. Monitor blood pressure and serum creatinine and potassium if use is prolonged.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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