Drug interactions
Aspirin / citric acid / sodium bicarbonate + Hydrochlorothiazide-losartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product, at analgesic doses, may reduce the antihypertensive effect of losartan and hydrochlorothiazide and may impair renal function in elderly or volume-depleted patients. The sodium load may also work against blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal vasodilatory prostaglandins, reducing renal perfusion and sodium excretion; the sodium content adds to fluid retention.
What to do
Limit use to short courses and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic if use is frequent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product, at analgesic doses, may reduce the antihypertensive effect of losartan and hydrochlorothiazide and may impair renal function in elderly or volume-depleted patients. The sodium load may also work against blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit use to short courses and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic if use is frequent.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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