Drug interactions
Aspirin / citric acid / sodium bicarbonate + Irbesartan
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product is given at analgesic doses and can weaken irbesartan's antihypertensive effect and worsen renal function, particularly in elderly or dehydrated patients. The sodium load may also modestly oppose blood pressure control.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin inhibits renal prostaglandin synthesis, reducing renal perfusion and sodium excretion; the sodium content adds to fluid retention.
What to do
Avoid regular use where possible and choose paracetamol for occasional pain. If used, monitor blood pressure, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Irbesartan?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product is given at analgesic doses and can weaken irbesartan's antihypertensive effect and worsen renal function, particularly in elderly or dehydrated patients. The sodium load may also modestly oppose blood pressure control.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible and choose paracetamol for occasional pain. If used, monitor blood pressure, renal function and potassium.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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