Drug interactions
Aspirin / citric acid / sodium bicarbonate + Ketoprofen
Severity: Major
Aspirin / citric acid / sodium bicarbonate and Ketoprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product adds to ketoprofen's gastrointestinal bleeding and ulcer risk, and ketoprofen may blunt aspirin's antiplatelet effect. Analgesic dose aspirin also increases renal risk.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive COX inhibition impairs mucosal protection and platelet function; ketoprofen competes with aspirin at COX-1.
What to do
Avoid concurrent use of two NSAIDs for analgesia. If low-dose aspirin is needed for cardioprotection, separate dosing from the NSAID and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Ketoprofen?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The aspirin in this effervescent product adds to ketoprofen's gastrointestinal bleeding and ulcer risk, and ketoprofen may blunt aspirin's antiplatelet effect. Analgesic dose aspirin also increases renal risk.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs for analgesia. If low-dose aspirin is needed for cardioprotection, separate dosing from the NSAID and consider gastroprotection.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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