Drug interactions
Ketoprofen + Ketorolac
Severity: Contraindicated
Ketoprofen and Ketorolac: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two NSAIDs together increases gastrointestinal bleeding, renal injury and cardiovascular risk without improving pain relief. Ketorolac labeling prohibits concurrent use with other NSAIDs.
What this interaction means in plain words
Ketoprofen and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoprofen belongs to Musculoskeletal; Ketorolac belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Do not combine; use a single NSAID at the lowest effective dose. Stop the other NSAID before ketorolac.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
- Amiloride + Ketoprofen Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketoprofen with Ketorolac?
MediHelp rates the interaction as contraindicated. Ketoprofen and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Using two NSAIDs together increases gastrointestinal bleeding, renal injury and cardiovascular risk without improving pain relief. Ketorolac labeling prohibits concurrent use with other NSAIDs.
How serious is the interaction between Ketoprofen and Ketorolac?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a single NSAID at the lowest effective dose. Stop the other NSAID before ketorolac.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac intranasal, Aceclofenac, Acemetacin. The full list is on the Ketoprofen page.
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