Drug interactions
Aspirin / citric acid / sodium bicarbonate + Mifepristone
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Effervescent aspirin has a systemic antiplatelet effect that could increase bleeding after mifepristone-induced abortion.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aspirin irreversibly inhibits platelet cyclooxygenase, adding to bleeding from the uterus after mifepristone.
What to do
Use paracetamol for pain or fever instead. If aspirin is essential, monitor bleeding and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Mifepristone?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Effervescent aspirin has a systemic antiplatelet effect that could increase bleeding after mifepristone-induced abortion.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use paracetamol for pain or fever instead. If aspirin is essential, monitor bleeding and hemoglobin.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
