Drug interactions
Aspirin / citric acid / sodium bicarbonate + Pemetrexed
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product may reduce pemetrexed clearance, raising the risk of myelosuppression and renal and GI toxicity. Patients with mild to moderate renal impairment are most vulnerable.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal elimination of pemetrexed.
What to do
Avoid the product around pemetrexed dosing where possible; monitor blood counts and renal function if it must be used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Pemetrexed?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product may reduce pemetrexed clearance, raising the risk of myelosuppression and renal and GI toxicity. Patients with mild to moderate renal impairment are most vulnerable.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the product around pemetrexed dosing where possible; monitor blood counts and renal function if it must be used.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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