Drug interactions
Ciltacabtagene autoleucel + Pemetrexed
Severity: Major
Ciltacabtagene autoleucel and Pemetrexed: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemetrexed is a myelosuppressive antimetabolite that can impair the expansion and function of CAR T cells and increase infection risk. Chemotherapy around the time of CAR T infusion can reduce the efficacy of the cell product and worsen cytopenias.
What this interaction means in plain words
Ciltacabtagene autoleucel and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciltacabtagene autoleucel belongs to Miscellaneous; Pemetrexed belongs to Oncology.
Why it happens
Cytotoxic and myelosuppressive effects of pemetrexed may reduce CAR T-cell persistence and add to immunosuppression.
What to do
Avoid giving pemetrexed around leukapheresis and during the period after CAR T infusion unless clearly needed. Monitor blood counts and screen for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pemetrexed
Other interactions of Ciltacabtagene autoleucel
Frequently asked questions
Can I take Ciltacabtagene autoleucel with Pemetrexed?
MediHelp rates the interaction as major. Ciltacabtagene autoleucel and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemetrexed is a myelosuppressive antimetabolite that can impair the expansion and function of CAR T cells and increase infection risk. Chemotherapy around the time of CAR T infusion can reduce the efficacy of the cell product and worsen cytopenias.
How serious is the interaction between Ciltacabtagene autoleucel and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving pemetrexed around leukapheresis and during the period after CAR T infusion unless clearly needed. Monitor blood counts and screen for infection.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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