Drug interactions
Aspirin / citric acid / sodium bicarbonate + Pralatrexate
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin component can reduce renal elimination of pralatrexate, increasing exposure and the risk of mucositis and myelosuppression.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate competition for renal tubular secretion and effects on renal function reduce pralatrexate clearance.
What to do
Prefer paracetamol for analgesia during pralatrexate therapy. If aspirin is needed, monitor for mucositis, blood counts and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Pralatrexate?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin component can reduce renal elimination of pralatrexate, increasing exposure and the risk of mucositis and myelosuppression.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol for analgesia during pralatrexate therapy. If aspirin is needed, monitor for mucositis, blood counts and renal function.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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