Drug reference
pralatrexate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Metabolite)
Mechanism of action
Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase (DHFR) selectively in cancer cells overexpressing the reduced folate carrier protein-1 (RFC-1)
Common side effects
- Constipation
- Anemia
- Fatigue
- Nausea
- Thrombocytopenia
- Inflammatory disease of mucous membrane
Related conditions
Frequently asked questions
What drug class is pralatrexate?
pralatrexate belongs to: Oncology.
How does pralatrexate work?
Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase (DHFR) selectively in cancer cells overexpressing the reduced folate carrier protein-1 (RFC-1)
What are the common side effects of pralatrexate?
Constipation, Anemia, Fatigue, Nausea, Thrombocytopenia, Inflammatory disease of mucous membrane
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