Drug interactions
Diflunisal + Pralatrexate
Severity: Major
Diflunisal and Pralatrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
What this interaction means in plain words
Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal blood flow decrease pralatrexate clearance.
What to do
Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Diflunisal with Pralatrexate?
MediHelp rates the interaction as major. Diflunisal and Pralatrexate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can delay renal elimination of pralatrexate, raising its exposure and the risk of toxicities such as mucositis and myelosuppression.
How serious is the interaction between Diflunisal and Pralatrexate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor for pralatrexate toxicity and renal function and adjust the pralatrexate dose as needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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