Drug interactions
Aspirin / citric acid / sodium bicarbonate + Probenecid
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The aspirin in this effervescent product competes with probenecid for renal tubular secretion and can blunt its uricosuric effect. Gout control may worsen with the analgesic doses typically used.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate competes with probenecid for renal tubular anion transport, antagonizing uricosuria.
What to do
Avoid this product in patients taking probenecid for gout and choose paracetamol for analgesia. Monitor serum urate if use is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Probenecid?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The aspirin in this effervescent product competes with probenecid for renal tubular secretion and can blunt its uricosuric effect. Gout control may worsen with the analgesic doses typically used.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid this product in patients taking probenecid for gout and choose paracetamol for analgesia. Monitor serum urate if use is unavoidable.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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