Drug interactions
Aspirin / citric acid / sodium bicarbonate + Sulindac
Severity: Major
Aspirin / citric acid / sodium bicarbonate and Sulindac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This effervescent aspirin product delivers a full analgesic dose of aspirin, which, with sulindac, raises the risk of gastrointestinal ulceration and bleeding. The NSAID may also interfere with aspirin's antiplatelet effect.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition and platelet dysfunction with gastrointestinal mucosal injury.
What to do
Avoid concurrent use and select a single NSAID or a non-NSAID analgesic. If combined, give gastroprotection and monitor for GI bleeding and anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin / citric acid / sodium bicarbonate and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Sulindac?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This effervescent aspirin product delivers a full analgesic dose of aspirin, which, with sulindac, raises the risk of gastrointestinal ulceration and bleeding. The NSAID may also interfere with aspirin's antiplatelet effect.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select a single NSAID or a non-NSAID analgesic. If combined, give gastroprotection and monitor for GI bleeding and anemia.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
