Drug interactions
Aspirin / citric acid / sodium bicarbonate + Tolazamide
Severity: Moderate
Aspirin / citric acid / sodium bicarbonate and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These effervescent products deliver analgesic doses of aspirin, which can enhance the glucose-lowering action of sulfonylureas and cause hypoglycemia. The effect is greater with repeated or high daily dosing.
What this interaction means in plain words
Aspirin / citric acid / sodium bicarbonate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate may displace sulfonylurea from protein binding and has intrinsic glucose-lowering effects.
What to do
Monitor blood glucose during regular use of the aspirin product. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Aspirin / citric acid / sodium bicarbonate with Tolazamide?
MediHelp rates the interaction as moderate. Aspirin / citric acid / sodium bicarbonate and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. These effervescent products deliver analgesic doses of aspirin, which can enhance the glucose-lowering action of sulfonylureas and cause hypoglycemia. The effect is greater with repeated or high daily dosing.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during regular use of the aspirin product. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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