Drug interactions
Insulin degludec-liraglutide + Tolazamide
Severity: Major
Insulin degludec-liraglutide and Tolazamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolazamide is a sulfonylurea that stimulates insulin release, and combining it with insulin and liraglutide increases the risk of hypoglycemia, which can be severe. The risk is highest when therapy is started or intensified.
What this interaction means in plain words
Insulin degludec-liraglutide and Tolazamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-induced insulin secretion, exogenous insulin and GLP-1 receptor agonism.
What to do
Consider reducing the tolazamide dose, or the insulin dose, when combining them. Monitor blood glucose closely and teach the patient to recognize and treat hypoglycemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
- Alogliptin-metformin + Tolazamide Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Tolazamide?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Tolazamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tolazamide is a sulfonylurea that stimulates insulin release, and combining it with insulin and liraglutide increases the risk of hypoglycemia, which can be severe. The risk is highest when therapy is started or intensified.
How serious is the interaction between Insulin degludec-liraglutide and Tolazamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the tolazamide dose, or the insulin dose, when combining them. Monitor blood glucose closely and teach the patient to recognize and treat hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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