Drug interactions
Disopyramide + Tolazamide
Severity: Major
Disopyramide and Tolazamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia, particularly in older patients and those with renal impairment, and may add to the effect of sulfonylureas. Severe episodes have been reported.
What this interaction means in plain words
Disopyramide and Tolazamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Tolazamide belongs to Endocrine.
Why it happens
Additive hypoglycemia, as disopyramide may increase insulin secretion.
What to do
Monitor blood glucose closely, especially in older patients or those with renal impairment. Reduce the tolazamide dose or consider another antiarrhythmic if hypoglycemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tolazamide
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
- Alogliptin-metformin + Tolazamide Moderate
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Tolazamide?
MediHelp rates the interaction as major. Disopyramide and Tolazamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide can cause hypoglycemia, particularly in older patients and those with renal impairment, and may add to the effect of sulfonylureas. Severe episodes have been reported.
How serious is the interaction between Disopyramide and Tolazamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, especially in older patients or those with renal impairment. Reduce the tolazamide dose or consider another antiarrhythmic if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Insulin degludec-liraglutide, Aceclofenac, Acemetacin. The full list is on the Tolazamide page.
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