Drug interactions
Aspirin rectal + Benazepril
Severity: Moderate
Aspirin rectal and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and at analgesic doses can reduce benazepril efficacy and renal function. Low antiplatelet doses carry little risk.
What this interaction means in plain words
Aspirin rectal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal perfusion and opposes ACE inhibitor vasodilation.
What to do
Monitor blood pressure, creatinine and potassium if higher doses are used repeatedly. Keep hydration adequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Aspirin rectal with Benazepril?
MediHelp rates the interaction as moderate. Aspirin rectal and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and at analgesic doses can reduce benazepril efficacy and renal function. Low antiplatelet doses carry little risk.
How serious is the interaction between Aspirin rectal and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium if higher doses are used repeatedly. Keep hydration adequate.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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