Drug interactions
Aspirin rectal + Candesartan-hydrochlorothiazide
Severity: Moderate
Aspirin rectal and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed rectal aspirin at analgesic doses can reduce the blood pressure lowering effect of candesartan and hydrochlorothiazide and can worsen renal function when the patient is volume depleted. Effects on potassium are variable.
What this interaction means in plain words
Aspirin rectal and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal perfusion and sodium excretion, opposing the antihypertensive and diuretic effects and increasing risk of kidney injury.
What to do
Avoid regular high-dose aspirin where possible. Monitor blood pressure, creatinine and potassium if used repeatedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin rectal with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin rectal and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemically absorbed rectal aspirin at analgesic doses can reduce the blood pressure lowering effect of candesartan and hydrochlorothiazide and can worsen renal function when the patient is volume depleted. Effects on potassium are variable.
How serious is the interaction between Aspirin rectal and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular high-dose aspirin where possible. Monitor blood pressure, creatinine and potassium if used repeatedly.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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