Drug interactions
Aspirin rectal + Cefixime
Severity: Minor
Aspirin rectal and Cefixime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin delivers salicylate systemically, which is cleared partly by tubular secretion shared with cefixime. Competition could marginally raise levels of either drug, with little expected clinical effect.
What this interaction means in plain words
Aspirin rectal and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport.
What to do
No routine action is needed; monitor for salicylate toxicity signs (tinnitus) with high-dose use or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Aspirin rectal with Cefixime?
MediHelp rates the interaction as minor. Aspirin rectal and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rectal aspirin delivers salicylate systemically, which is cleared partly by tubular secretion shared with cefixime. Competition could marginally raise levels of either drug, with little expected clinical effect.
How serious is the interaction between Aspirin rectal and Cefixime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; monitor for salicylate toxicity signs (tinnitus) with high-dose use or renal impairment.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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