Drug interactions
Aspirin rectal + Celecoxib
Severity: Moderate
Aspirin rectal and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically, so it adds to celecoxib the risk of gastrointestinal ulceration and bleeding. The combination offsets some of celecoxib's gastric safety advantage.
What this interaction means in plain words
Aspirin rectal and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive mucosal injury and aspirin-induced irreversible platelet inhibition on top of NSAID effects.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for bleeding. Avoid unnecessary combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Aspirin rectal with Celecoxib?
MediHelp rates the interaction as moderate. Aspirin rectal and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically, so it adds to celecoxib the risk of gastrointestinal ulceration and bleeding. The combination offsets some of celecoxib's gastric safety advantage.
How serious is the interaction between Aspirin rectal and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and monitor for bleeding. Avoid unnecessary combined use.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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