Drug interactions
Aspirin rectal + Cilostazol
Severity: Moderate
Aspirin rectal and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol and aspirin are frequently combined in vascular and stroke indications, and the combination mildly increases bleeding risk. Serious bleeding is not common but is possible.
What this interaction means in plain words
Aspirin rectal and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: PDE3 inhibition by cilostazol plus cyclooxygenase inhibition by aspirin.
What to do
Use together only when indicated and monitor for bleeding; consider gastroprotection in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aspirin rectal and Cilostazol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cilostazol
Frequently asked questions
Can I take Aspirin rectal with Cilostazol?
MediHelp rates the interaction as moderate. Aspirin rectal and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cilostazol and aspirin are frequently combined in vascular and stroke indications, and the combination mildly increases bleeding risk. Serious bleeding is not common but is possible.
How serious is the interaction between Aspirin rectal and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when indicated and monitor for bleeding; consider gastroprotection in at-risk patients.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
