Drug interactions
Aspirin rectal + Hydrochlorothiazide-losartan
Severity: Moderate
Aspirin rectal and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin is absorbed systemically and can have the same renal prostaglandin effects as oral aspirin. At analgesic doses it may weaken blood pressure control and impair renal function when combined with losartan and hydrochlorothiazide.
What this interaction means in plain words
Aspirin rectal and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and natriuresis, antagonizing diuretic and ARB effects.
What to do
Monitor blood pressure, serum creatinine and potassium if repeated doses are used. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Aspirin rectal with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Aspirin rectal and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin is absorbed systemically and can have the same renal prostaglandin effects as oral aspirin. At analgesic doses it may weaken blood pressure control and impair renal function when combined with losartan and hydrochlorothiazide.
How serious is the interaction between Aspirin rectal and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium if repeated doses are used. Ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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