Drug interactions
Aspirin rectal + Imatinib
Severity: Moderate
Aspirin rectal and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib can cause thrombocytopenia and bleeding, and aspirin inhibits platelet function. Systemic absorption of rectal aspirin still increases bleeding risk.
What this interaction means in plain words
Aspirin rectal and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis: imatinib-related thrombocytopenia plus aspirin platelet inhibition.
What to do
Monitor platelet counts and for signs of bleeding. Use aspirin only where clearly indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Aspirin rectal with Imatinib?
MediHelp rates the interaction as moderate. Aspirin rectal and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib can cause thrombocytopenia and bleeding, and aspirin inhibits platelet function. Systemic absorption of rectal aspirin still increases bleeding risk.
How serious is the interaction between Aspirin rectal and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and for signs of bleeding. Use aspirin only where clearly indicated.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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